QFT and children; another key milestone passed

From Finland a study of children aged 0 - 18 titled "IGRA tests perform similarly to TST but cause no adverse reactions: pediatric experience in Finland"

Our study raises several important issues. When performing TST, intradermal inoculation of PPD in children exposed to M. tuberculosis may produce an excessive delayed type hypersensitivity reaction. Secondly, demonstration of the test variability around the cut-off zone in real laboratory settings convinces that interpretation of immunodiagnostic methods should take into account the method imprecision and utilize a grey zone.

Conclusions
The sensitivity and specificity of IGRA methods compares well with TST but do not cause
exaggerated delayed type hypersensitivity reactions.