nearly one-third of our TB patients were still positive by QFT-G assay despite active TB disease treatment....the present study suggests that the decrease in the M. tuberculosis-specific T cells responses following successful anti-TB therapy may have a clinical value as a supplemental tool for the monitoring of the efficacy of pharmacologic intervention for active TB.Having a control group strengthens the validity of the study and amongst those who had active TB were those with both pulmonary and non pulmonary TB and with and without prior BCG vaccination.
Following proper analysis of the data the researchers had no option but to challenge the efficacy of current TB treatment and therefore the orthodoxy of specifiers and practitioners of TB treatment;
the antituberculous drugs do not have any direct effect on host immune response
