Comparison of an IGRA with TST in HCWs with a high rate of BCG vaccination.

Whilst the study used T-Spot TB as the IGRA (QuantiFERON or ELISpot-Plus are also IGRAs) the results were unequivocal;

The high rate of positive baseline TST results in our BCG-vaccinated healthcare workers renders the TST unsuitable as a surveillance tool in this tuberculosis risk group. Use of an IGRA has enabled the detection and treatment of latent tuberculosis in this group.

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