Seachange for QuantiFERON

It wasnt that long ago that Mayo were "cool" on QFT

Technically difficult assay to perform

Now it is the TST that is copping some heat;

While reading a TST is often assumed to be an easy task, accurate measurement of the reaction requires highly trained medical personnel. Furthermore, even when performed by well-trained individuals, TST interpretation is still somewhat subjective and can be inaccurate. In addition, many patients do not return for the second visit, presenting patient follow-up concerns.

By comparison QFT is streets ahead

Because it is laboratory-based, the QuantiFERON test (QFT) is not subject to many of the problems associated with the TST

Mayo have really stepped up to the plate with QFT and almost sound enthusiastic

The landscape of tuberculosis testing is changing. Recently introduced in vitro technology advances the field of TB diagnostics and the QFT may replace the TST in certain populations.

I wonder if its a new generation of doctors that are seizing the moment, certainly QFT has changed the way that the medical community view TB

QFT use increases the role of the clinical laboratory in TB control.

Not only is QFT easier to use it is more accurate

Apart from the operational advantages over the TST, the QFT-G and QFT-GIT have excellent specificity in previously BCG-vaccinated individuals and do not react with most nontuberculous mycobacteria.

The 2010 Mayo communique can be read in full here

Hat tip Doc GT

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