In their
meta-analysis:
New Tests for the Diagnosis of Latent Tuberculosis Infection: Areas of Uncertainty and Recommendations for Research the authors comment on discordant results between IGRA and TST
Discordant tuberculin skin test and IGRA reactions were frequent and largely unexplained
The study
Evaluating the non-tuberculous mycobacteria effect in the tuberculosis infection diagnosis just
published in the peer reviewed
ERS Journal explains that discrepancy
In summary, our results show enough evidence to state that previous NTM sensitisation in children induces false-positive results in the TST for diagnosing LTBI and that the IFN-y tests could avoid both unnecessary chemoprophylaxis treatment among child populations and consuming resources searching the index case.
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