Except that forest saw it.
It is worth looking back at what Dick Menzies had to say about the first Diel paper
The results of Diel and colleagues are very promising, as they suggest the potential for IGRAs to enable programs to target the highest-risk patients for latent TB treatment. These findings do not call, they shout, for further prospective studies to better define the ability of IGRAs, relative to the TST, to predict future risk of active TB.Well 2 years later there is now something to really shout about
Presented at the British Thoracic Society’s London meeting in November, this exciting study compared QFT and the TST progression rates to active TB in contact screening. The data show QFT to have 100% negative predictive value because none who tested QFT-negative (or QFT-negative/TST-positive) progressed to active TB (n = 835). The key finding is that QFT is highly predictive of active TB; a sixth of “QFT Positive” contacts, left untreated, progress to active TB within 2 years, a rate which compares favorably with that observed with TST (1 in 50–100 cases).
