Sensitivity of the IGRA for TB disease was no different from TST, and a significantly reduced IGRA sensitivity was found in high-burden TB settings compared with low-burden TB settings. Further studies are needed to determine the value of IGRAs in LTBI and TB disease diagnosis in children.Dearie me, these characters have concluded that there is evidence that IGRA and TST are comparable with active TB whilst there is no evidence to suggest that IGRA is better than the TST in latent TB. For some reason they felt that IGRA should be used for disease when it's described function is that it accurately identifies people infected with Mycobacterium tuberculosis.
Is it worth reading the whole study? Probably not as they seek refuge behind the old caveat there is no gold standard for latent TB
