These preliminary data suggest that the rate of LTBI among adult immigrants from TB endemic countries, in our stusy most of them also close contacts of active TB cases, is significantly lower when detected by QFT-IT, than by TST. Moreover, our findings suggest that using an IGRA test for LTBI screening in this high risk population might reduce the number of candidates to preventive treatment and can provide potential substantial benefits for TB control.
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Incidence Of Active Tuberculosis Among High-Risk Immigrants Screened For Latent Tuberculosis Infection Using Interferon-Gamma Release Assays
Although we identified a small number of TB cases during follow-up, the incidence rates of active TB among patients not treated for LTBI were higher than expected. TB control programs should consider LTBI preventive therapy for all high-risk immigrants with positive IGRA results, regardless of prior treatment history. Additional research is needed to clarify the incidence of and risk factors for active TB among high-risk immigrants with negative IGRA results.
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